Formate dehydrogenase (cytochrome)

In enzymology, a formate dehydrogenase (cytochrome) (EC 1.2.2.1) is an enzyme that catalyzes the chemical reaction

formate + 2 ferricytochrome b₁ ⇌ CO₂ + 2 ferrocytochrome b₁ + 2 H⁺

Thus, the two substrates of this enzyme are formate and ferricytochrome b1, whereas its 3 products are CO₂, ferrocytochrome b1, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with a cytochrome as acceptor. The systematic name of this enzyme class is formate:ferricytochrome-b1 oxidoreductase. Other names in common use include formate dehydrogenase, and formate:cytochrome b1 oxidoreductase. This enzyme participates in glyoxylate and dicarboxylate metabolism.