Ford F Series (eleventh generation)

The redesigned eleventh generation F-150, using the new P2 platform, was introduced by Ford in January 2003 at the North American International Auto Show. Designed by Tyler Blake under Patrick Schiavone between 1999 and January 2000, the styling was a revolutionary, more angular update of the PN-96. On August 29, 2000, the final production design was frozen. Development began in 1997, with scheduled production for September 2002 alongside the U222 Expedition. Development later ended in 2003 due to delays. The side windows also changed to a Kenworth "Daylight Door" and Ford Super Duty-like appearance; dipping towards the front of the door. Initially, only Ford's 4.6 L Triton or new 3-valve 5.4 L 3V Triton V8 engines and four-speed automatic transmissions were offered to the retail public on the new trucks. For the 2005 model year, Ford's 4.2 L Essex V6 and manual transmission became available and standard on base models after they were available only for fleet orders for 2004 and automatic headlamps became available. The 11th generation F-150 is the last vehicle Ford manufactured with a gasoline pushrod V6.

The F-250 and F-350 Ford Super Duties (on the P3 platform) are a different class (over 8,500 lb (3,900 kg) GVWR) than the regular F-series lineup, although they are still F-series trucks.

Most F-Series have two large "closed loop" front tow hook design (no hooks on some 4x2 models) as opposed to conventional open hooks.

For the 2006 model year beginning in December, 2005, a flex-fuel version of the 3-valve 5.4 L Triton V8 became available, and the SuperCrew model was made available with the 6.5' box. Also for the 2006 model year, an updated front bumper with circular fog lamps and a smaller bumper vent distinguished the 2006–2008 models from the 2004–2005 F-150. Other updates included improved front seats with more supportive side bolstering, and new 20" wheels available for FX4, Lariat and King Ranch. A navigation system became an option for the first time, being offered on the Lariat and King Ranch, as well as the all-new Harley Davidson trim. Not leaving the XLT unnoticed, Ford offered an XLT Chrome Package, also known as XTR in Canada, as well as a Lariat Chrome package. SIRIUS satellite radio became available on all trims except the XL. The FX4 became more upscale with a Luxury package, making it almost an alternative trim to the Lariat. A Harley-Davidson special edition was offered for 2006, being available in two- or all-wheel-drive, and only in SuperCab. Other mid-cycle refresh improvements included five-inch running boards, traction assist on 4x2 V8 models, and an all-new "Smokestone Clearcoat Metallic" paint on Lariat only.

For 2007, Ford introduced a complement to the existing FX4 model, the new FX2 Sport package (a 2-wheel-drive truck with an appearance package). A SuperCrew was offered in the Harley-Davidson trim as well. Ford states that a properly equipped 2007 F-150 (Regular cab or SuperCab 8' box 4x2) can tow up to 11,000 lb (5,000 kg) maximum and 1800–3050 lb maximum payload.

This generation F-150 got top safety ratings (5 stars) from the U.S. National Highway Traffic Safety Administration (NHTSA) in frontal collisions, and not only got a "Good" rating from the Insurance Institute for Highway Safety's frontal offset test, but also a Best Pick. The dummy sensors recorded no injuries to any body region.

Saleen offers their own OEM version of the F-150, badged as the S331. Additionally, Roush offers an aftermarket version with similar power. Beginning with the second half of the 2007 model year, Ford offered the Saleen forced-induction package on the Harley edition as an OEM option.

The F-150 Foose Edition debuted in fall 2007 as a 2008 model. Based on an F-150 FX2 Sport, it uses a Roush-developed powertrain. The supercharged 5.4 L V8 puts out 450 hp (340 kW) and 500 lb·ft (680 N·m) of torque.