ATC code N02BG04 (WHO) PubChem CID 3360 ChemSpider 3243 | CAS Number 23779-99-9 DrugBank DB08976 Molar mass 406.355 g/mol | |
AHFS/Drugs.com International Drug Names |
Floctafenine is a non-steroidal anti-inflammatory drug (NSAID).
Synthesis
The scheme involves first the conversion of ortho-trifluoromethyl aniline (1) to a quinolol. The compound is thus condensed with EMME (Ethoxy Methylene Malonic Diethyl Ester) and cyclized thermally (2). That intermediate is then saponified; the resulting acid is decarboxylated and finally converted to the 4-chloroquinoline (3) by reaction with phosphorus oxychloride. The displacement of chlorine with methyl anthranilate (4) then affords the coupled intermediate (5). An ester interchange of that product with glycerol leads to the glyceryl ester. There is thus obtained the NSAID floctafenine.
References
Floctafenine Wikipedia(Text) CC BY-SA