Flatow is a surname. Notable people with the surname include:
Alfred Flatow (1869–1942), German gymnast
Alisa Flatow (1975–1995), American student and terrorism victim
Curth Flatow (1920-2011), German dramatist and screenwriter
Evan Flatow (born 1956), American orthopaedic surgeon
Fred Flatow (born 1937), Australian-German chess master
Gustav Flatow (1875–1945), German gymnast
Ira Flatow (born 1949), radio and television journalist, NPR