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See also: Fioricet, a preparation using paracetamol (acetaminophen) instead of aspirin.
In the United States, Fiorinal is a combination analgesic medication consisting of aspirin, the barbiturate butalbital and caffeine, with or without codeine phosphate; in other countries the formulation may differ. For example, in Australia, Fiorinal consists of paracetamol, codeine phosphate, and the sedative antihistamine doxylamine. It is indicated for the treatment of tension headaches and is often used off-label (without approval by the U.S. Food and Drug Administration (FDA)) to treat migraines. The mechanism of action is not well understood. Since butalbital is habit-forming, using the United States Formulation of Fiorinal daily can lead to dependency. Fiorinal #3 contains: 30 mg codeine, 50 mg butalbital, 40 mg caffeine, and 325 mg aspirin.
Other brand names include Fiormor, Fiortal, Fortabs, and Laniroif.
In the United States, Fiorinal is manufactured by Actavis (formerly Watson Pharmaceuticals), owned by Allergan, plc, a subsidiary of Teva Pharmaceuticals as of July 2015.