Girish Mahajan (Editor)

Fatty acid oxidation inhibitors

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Fatty acid oxidation inhibitors are a new potent class of drugs used in treatment of stable angina pectoris and an addition in treatment of chronic heart failure.

Drugs

  • CPT-I inhibitors: Etomoxir, Oxfenicine, Perhexiline
    CPT-I (carnitine palmitoyl transferase) converts fatty acyl-CoA to fatty acyl-carnitine.
  • Carnitine biosynthesis inhibitor: Mildronate
  • 3-KAT inhibitors: Trimetazidine
    3-KAT (3-ketoacyl-coenzyme A thiolase) inhibitors directly inhibits fatty acid beta-oxidation.
  • pFOX (partial fatty acid oxidation inhibitors): Ranolazine
    pFOX directly inhibits fatty acid beta-oxidation.

    • References

    Fatty acid oxidation inhibitors Wikipedia
    (Text) CC BY-SA


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