Trade names Afobazole ATC code N05BX04 (WHO) Formula C15H21N3O2S | Routes of
administration Oral Metabolism Molar mass 307.41 g/mol | |
 | ||
Legal status US: Unscheduled Not FDA approved Bioavailability 43.64%, pronounced first-pass effect | ||
Fabomotizole (INN) (brand name Afobazole) is an anxiolytic drug launched in Russia in the early 2000s. It produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions. Its mechanism of action remains poorly defined however, with GABAergic, NGF- and BDNF-release-promoting, MT1 receptor agonism, MT3 receptor antagonism, and sigma agonism suggested as potential mechanisms. Fabomotizole was shown to inhibit MAO-A reversibly and there might be also some involvement with serotonin receptors. Clinical trials have shown fabomotizole to be well tolerated and reasonably effective for the treatment of anxiety.
Experiments of mice have shown antimutagenic and antiteratogenic properties.
Fabomotizole has found little clinical use outside Russia and has not been evaluated by the FDA.