Species Human Entrez 8325 | Human Mouse Ensembl ENSG00000177283 | |
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Aliases FZD8, FZ-8, hFZ8, frizzled class receptor 8 External IDs MGI: 108460 HomoloGene: 40606 GeneCards: FZD8 | ||
Frizzled-8 is a protein that in humans is encoded by the FZD8 gene.
Function
This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.
References
FZD8 Wikipedia(Text) CC BY-SA