Girish Mahajan (Editor)

FMO4

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Species
  
Human

Entrez
  
2329

Human
  
Mouse

Ensembl
  
ENSG00000076258

FMO4

Aliases
  
FMO4, FMO2, flavin containing monooxygenase 4

External IDs
  
MGI: 2429497 HomoloGene: 68219 GeneCards: FMO4

Dimethylaniline monooxygenase [N-oxide-forming] 4 is an enzyme that in humans is encoded by the FMO4 gene.

Function

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics.

References

FMO4 Wikipedia