Entrez 91010 | Ensembl ENSG00000161791 | |
Aliases FMNL3, FHOD3, WBP-3, WBP3, FRL2, formin like 3 External IDs MGI: 109569 HomoloGene: 69101 GeneCards: FMNL3 | ||
Formin-like protein 3 (FMNL3), also known as WW domain-binding protein 3 (WBP-3), is a protein that in humans is encoded by the FMNL3 gene.
Function
The protein encoded by this gene contains a formin homology 2 domain and has high sequence identity to the mouse Wbp3 protein. Two alternative transcripts encoding different isoforms have been described. The C-terminus has been shown to accelerate actin polymerization activity of this protein through its WH2-like motif. FMNL3 has been crystallized in complex with actin providing insight into the mechanism of formin-mediated actin nucleation.
References
FMNL3 Wikipedia(Text) CC BY-SA