Supriya Ghosh (Editor)

FLNB

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Species
  
Human

Entrez
  
2317

Human
  
Mouse

Ensembl
  
ENSG00000136068

FLNB

Aliases
  
FLNB, ABP-278, ABP-280, AOI, FH1, FLN-B, FLN1L, LRS1, SCT, TABP, TAP, filamin B

External IDs
  
MGI: 2446089 HomoloGene: 37480 GeneCards: FLNB

Filamin B, beta (FLNB), also known as Filamin B, beta (actin binding protein 278), is a cytoplasmic protein which in humans is encoded by the FLNB gene.

FLNB regulates intracellular communication and signalling by cross-linking the protein actin to allow direct communication between the cell membrane and cytoskeletal network, to control and guide proper skeletal development.

Mutations in the FLNB gene are involved in several lethal bone dysplasias, including boomerang dysplasia and atelosteogenesis type I.

Interactions

FLNB has been shown to interact with GP1BA, Filamin, FBLIM1, PSEN1, CD29 and PSEN2.

References

FLNB Wikipedia