Entrez 9638 | Ensembl ENSG00000149557 | |
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External IDs MGI: 2670976 HomoloGene: 21063 GeneCards: FEZ1 |
Fasciculation and elongation protein zeta-1 is a protein that in humans is encoded by the FEZ1 gene.
This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described.
This protein is present in neurons, and it is believed to block the process of infection of these cells by HIV.
References
FEZ1 Wikipedia(Text) CC BY-SA