Species Human Entrez 26234 | Human Mouse Ensembl ENSG00000118564 | |
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Aliases FBXL5, FBL4, FBL5, FLR1, F-box and leucine-rich repeat protein 5, F-box and leucine rich repeat protein 5 External IDs MGI: 2152883 HomoloGene: 8129 GeneCards: FBXL5 | ||
F-box/LRR-repeat protein 5 is a protein that in humans is encoded by the FBXL5 gene.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternative splicing of this gene generates 2 transcript variants.
FBXL5 is an iron sensor. It promotes IRP2 ubiquitination and then its degradation.