Entrez 84895 | Ensembl ENSG00000148343 | |
Aliases MIGA2, C9orf54, FAM73B, family with sequence similarity 73 member B, mitoguardin 2 External IDs MGI: 1922035 HomoloGene: 13125 GeneCards: MIGA2 | ||
family with sequence similarity 73, member B, also known as FAM73B, is a human gene.
Model organisms
Model organisms have been used in the study of FAM73B function. A conditional knockout mouse line, called Fam73btm1a(KOMP)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty four tests were carried out on mutant mice and six significant abnormalities were observed. Homozygous mutant animals had a decreased body weight, altered body composition, abnormal tooth morphology, hypoalbuminemia, decreased bone mineral content and strength, and an increased susceptibility to bacterial infection.