Species Human Entrez 9002 | Human Mouse Ensembl ENSG00000127533 | |
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Aliases F2RL3, PAR4, F2R like thrombin/trypsin receptor 3 External IDs MGI: 1298207 HomoloGene: 36148 GeneCards: F2RL3 | ||
Protease-activated receptor 4 (PAR-4), also known as coagulation factor II (thrombin) receptor-like 3, is a protein that in humans is encoded by the F2RL3 gene.
Function
Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin.
References
F2RL3 Wikipedia(Text) CC BY-SA