Species Human Entrez 2151 | Human Mouse Ensembl ENSG00000164220 | |
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Aliases F2RL2, PAR-3, PAR3, coagulation factor II thrombin receptor like 2 External IDs MGI: 1298208 HomoloGene: 36151 GeneCards: F2RL2 | ||
Protease activated receptor 3 (PAR-3) also known as coagulation factor II receptor-like 2 (F2RL2) and thrombin receptor-like 2, is a protein that in humans is encoded by the F2RL2 gene.
Function
Coagulation factor II (thrombin) receptor-like 2 (F2RL2) is a member of the large family of 7-transmembrane receptors that couple to G proteins. F2RL2 is also a member of the protease-activated receptor family and activated by thrombin. F2RL2 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL2 is a cofactor for F2RL3 activation by thrombin. It mediates thrombin-triggered phosphoinositide hydrolysis and is expressed in a variety of tissues.
References
F2RL2 Wikipedia(Text) CC BY-SA