Examples of in vivo transdifferentiation by lineage instructive approach

Updated on Dec 16, 2024

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A list of examples of in vivo transdifferentiation through transfection:

mouse hepatocytes → B cells (Pdx1)

exocrine cells → B cells (Pdx1, Ngn3, and v-maf musculoaponeurotic fibrosarcoma oncogene family protein A)

nonsensory cells → inner hair cells (Atoh1 and MathI)

non cardiogenic mesoderm → cardiomyocytes (Gata4, Tbx5 and Smarcd3 or Baf60c)

Through excision:

B-cell precursors → hematopoietic progenitors(-Pax5)

In adult ovarian follicles, granulosa and thecal cells → functional Sertoli-like and Leydig-like cells (-Foxl1)

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