Examples of in vitro transdifferentiation by initial epigenetic activation phase approach

Updated on Jan 11, 2024

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Human dermal fibroblasts → multilineage blood progenitors (Oct4 and cytokine treatment)

Mouse dermal fibroblasts → polygonal hyaline chondrogenic cells (Klf4, c-Myc, Sox9)

Mouse dermal fibroblasts → cardiomyocytes (Oct4, Sox2, Klf4, JI1 and Bmp4)

Fibroblasts → neural stem/progenitor cells (Oct4, Sox2, c-Myc, Klf4)

References

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