EC number 2.8.2.4 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 9026-06-6 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, an estrone sulfotransferase (EC 2.8.2.4) is an enzyme that catalyzes the chemical reaction
3'-phosphoadenylyl sulfate + estroneThus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and estrone, whereas its two products are adenosine 3',5'-bisphosphate and estrone 3-sulfate.
This enzyme belongs to the family of transferases, to be specific, the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:estrone 3-sulfotransferase. Other names in common use include 3'-phosphoadenylyl sulfate-estrone 3-sulfotransferase, estrogen sulfotransferase, estrogen sulphotransferase, oestrogen sulphotransferase, and 3'-phosphoadenylylsulfate:oestrone sulfotransferase. This enzyme participates in androgen and estrogen metabolism and sulfur metabolism.
Structural studies
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1AQU, 1AQY, 1BO6, 1G3M, and 1HY3.