Estradiol 17alpha dehydrogenase

In enzymology, an estradiol 17alpha-dehydrogenase (EC 1.1.1.148) is an enzyme that catalyzes the chemical reaction

The three substrates of this enzyme are estradiol-17alpha, NAD⁺, and NADP⁺, whereas its four products are estrone, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 17alpha-hydroxysteroid:NAD(P)⁺ 17-oxidoreductase. Other names in common use include 17alpha-estradiol dehydrogenase, 17alpha-hydroxy steroid dehydrogenase, 17alpha-hydroxy steroid oxidoreductase, 17alpha-hydroxysteroid oxidoreductase, and estradiol 17alpha-oxidoreductase. This enzyme participates in androgen and estrogen metabolism.