Eschenbach is German surname. Notable people with the surname include:
Wolfram von Eschenbach (c. 1160–1220), German knight, poet and Minnesinger
Marie von Ebner-Eschenbach (1830–1916), Austrian writer
Christoph Eschenbach (b. 1940), German pianist and conductor
Andrew von Eschenbach, former Director of the U.S. National Cancer Institute, Commissioner of the U.S. Food and Drug Administration (FDA) from 2006-2009, Director at BioTime, 2011-present