Esch is a surname. Notable people with the surname include:
En Esch
Eric Esch, American boxer better known as Butterbean
Jim Esch
Johann Esch (died 1523), one of the first two Lutheran martyrs
John J. Esch
Marvin L. Esch (born 1927), U.S. Representative from Michigan
Nicolaus van Esch (1507–1578), Dutch theologian
Hansjoachim von der Esch (1899–1976), German explorer