Erythrose 4 phosphate dehydrogenase

In enzymology, an erythrose-4-phosphate dehydrogenase (EC 1.2.1.72) is an enzyme that catalyzes the chemical reaction

D-erythrose 4-phosphate + NAD⁺ + H₂O ⇌ 4-phosphoerythronate + NADH + 2 H⁺

The 3 substrates of this enzyme are D-erythrose 4-phosphate, NAD⁺, and H₂O, whereas its 3 products are 4-phosphoerythronat, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-erythrose 4-phosphate:NAD+ oxidoreductase. Other names in common use include erythrose 4-phosphate dehydrogenase, E4PDH, GapB, Epd dehydrogenase, and E4P dehydrogenase. This enzyme participates in vitamin B₆ metabolism (see DXP-dependent biosynthesis of pyridoxal phosphate).