EC number 2.3.1.94 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 87683-77-0 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, an erythronolide synthase (EC 2.3.1.94) is an enzyme that catalyzes the chemical reaction
6 malonyl-CoA + propanoyl-CoAThus, the two substrates of this enzyme are malonyl-CoA and propanoyl-CoA, whereas its two products are CoA and 6-deoxyerythronolide b.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is malonyl-CoA:propanoyl-CoA malonyltransferase (cyclizing). Other names in common use include erythronolide condensing enzyme, and malonyl-CoA:propionyl-CoA malonyltransferase (cyclizing). This enzyme participates in biosynthesis of 12-, 14- and 16-membered macrolides.
Structural studies
As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1KEZ, 1MO2, 1PZQ, 1PZR, 2HG4, 2JU1, 2JU2, and 2QO3.