Erythromycin 12 hydroxylase

Updated on Dec 20, 2024

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EC number 1.14.13.154 BRENDA BRENDA entry KEGG KEGG entry		IntEnz IntEnz view ExPASy NiceZyme view MetaCyc metabolic pathway

Erythromycin 12 hydroxylase (EC 1.14.13.154, EryK) is an enzyme with systematic name erythromycin-D,NADPH:oxygen oxidoreductase (12-hydroxylating) . This enzyme catalyses the following chemical reaction

erythromycin D + NADPH + H⁺ + O₂ ⇌ erythromycin C + NADP⁺ + H₂O

Erythromycin 12 hydroxylase is responsible for the C-12 hydroxylation of the macrolactone ring.

References

Erythromycin 12 hydroxylase Wikipedia

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