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Erythrocrine describes red blood cell or erythrocyte for production and release of signaling molecules. The term “erythrocrine“ was coined by Song et al. [1] in reference to erythrocyte, particularly the mature erythrocyte as a secretory cell, not just engaging in gaseous conveyance and exchange.
The erythrocyte is differentiated for such function to predominately express hemoglobin and remove all the organelle including protein synthesis machinery. Our traditional review of erythrocyte function is solely for gaseous exchange. Nevertheless, several previously undetected physiologic functions of erythrocyte are largely neglected.
The available literature data speak in favor of the unique behavior of erythrocrine. The seminal concept of erythrocrine may illuminate the unveiled exquisite molecular signaling of erythrocyte and expedite our understanding of the physiologic and pathophysiologic functions of erythrocyte.