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Epimysium (plural epimysia) (Greek epi- for on, upon, or above + Greek mys for muscle) The epimysium is the fibrous tissue envelope that surrounds skeletal muscle. It is a layer of dense irregular connective tissue which ensheathes the entire muscle and protects muscles from friction against other muscles and bones. It is continuous with fascia and other connective tissue wrappings of muscle including the endomysium and perimysium. It is also continuous with tendons, where it becomes thicker and collagenous.
While the epimysium is irregular on muscles, it is regular on tendons.