Rahul Sharma (Editor)

Epi isozizaene 5 monooxygenase

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EC number
  
1.14.13.106

IntEnz
  
IntEnz view

ExPASy
  
NiceZyme view

CAS number
  
1207718-51-1

BRENDA
  
BRENDA entry

KEGG
  
KEGG entry

Epi-isozizaene 5-monooxygenase (EC 1.14.13.106, CYP170A1) is an enzyme with systematic name (+)-epi-isozizaene,NADPH:oxygen oxidoreductase (5-hydroxylating). This enzyme catalyses the following chemical reaction

(+)-epi-isozizaene + 2 NADPH + 2 H+ + 2 O2 ⇌ albaflavenone + 2 NADP+ + 3 H2O (overall reaction) (1a) (+)-epi-isozizaene + NADPH + H+ + O2 ⇌ (5S)-albaflavenol + NADP+ + H2O (1b) (5S)-albaflavenol + NADPH + H+ + O2 ⇌ albaflavenone + NADP+ + 2 H2O (2a) (+)-epi-isozizaene + NADPH + H+ + O2 ⇌ (5R)-albaflavenol + NADP+ + H2O (2b) (5R)-albaflavenol + NADPH + H+ + O2 ⇌ albaflavenone + NADP+ + 2 H2O

This cytochrome P450 enzyme is purified from bacterium Streptomyces coelicolor.

References

Epi-isozizaene 5-monooxygenase Wikipedia
(Text) CC BY-SA