Ephron is a Jewish surname. Notable people with the surname include:
Ephron, Hittite who sold a cave to Abraham according to the Bible
A family of American writers:
Henry Ephron (1911–1992), father
Phoebe Ephron (1914–1971), mother
Amy Ephron (born 1952), daughter
Delia Ephron (born 1944), daughter
Hallie Ephron (born 1948), daughter, sometimes writes as G. H. Ephron
Nora Ephron (1941–2012), daughter
Theron Ephron Catlin (1878–1960), American politician from Missouri
