Entwistle is an English surname. Notable people with the surname include:
Alan Entwistle, British scholarBobby Entwistle, English footballerCyril Entwistle, British politicianDarren Entwistle, Canadian businessmanEdward Entwistle, English railroad engineerGeorge Entwistle, British television producerHarry Entwistle, English-born Australian priestJames F. Entwistle, American diplomatJohn Entwistle, the original bass guitarist of The WhoJonty Entwistle, English footballerNeil Entwistle, convicted of the murder of his wife and daughterNoel Entwistle, UK educational psychologistPeg Entwistle, British actressRobert Entwistle, English cricketerVicky Entwistle, British actressWayne Entwistle, English footballer