Harman Patil

Enoyl acyl carrier protein reductase

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EC number  1.3.1.9
IntEnz  IntEnz view
ExPASy  NiceZyme view
CAS number  37251-08-4
BRENDA  BRENDA entry
KEGG  KEGG entry
Enoyl-acyl carrier protein reductase

Enoyl-acyl carrier protein reductase (or ENR) (EC 1.3.1.9), is a key enzyme of the type II fatty acid synthesis (FAS) system. ENR is an attractive target for narrow-spectrum antibacterial drug discovery because of its essential role in metabolism and its sequence conservation across many bacterial species. In addition, the bacterial ENR sequence and structural organization are distinctly different from those of mammalian fatty acid biosynthesis enzymes.

At lower concentrations, Triclosan and Triclocarban provide a bacteriostatic effect by binding to ENR. Atromentin and leucomelone possess antibacterial activity, inhibiting the enzyme in the bacteria Streptococcus pneumoniae.

References

Enoyl-acyl carrier protein reductase Wikipedia


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