Routes ofadministration Oral CAS Number 220322-05-4 ChemSpider 5290108 | ATC code none PubChem CID 195441926914152 Molar mass 448.4085 g/mol | |
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Legal status In general: uncontrolled |
Elzasonan (CP-448,187) is a selective 5-HT1B and 5-HT1D receptor antagonist that was under development by Pfizer for the treatment of depression but was discontinued, possibly due to poor efficacy. By preferentially blocking 5-HT1B and 5-HT1D autoreceptors, elzasonan is thought to enhance serotonergic innervations originating from the raphe nucleus, thereby improving signaling to limbic regions like the hippocampus and prefrontal cortex and ultimately resulting in antidepressant effects.
References
Elzasonan Wikipedia(Text) CC BY-SA