Eizaguirre is a Spanish surname. Notable people with the surname include:
Agustín Eizaguirre (1897–1961), Spanish footballerGuillermo Eizaguirre (1909–1986), Spanish football goalkeeper and managerIgnacio Eizaguirre (1920–2013), Spanish football goalkeeperJose Echegaray y Eizaguirre (1832–1916), Spanish civil engineer, mathematician, statesman, and dramatistUnai Osa Eizaguirre (born 1975), Spanish former road bicycle racer