Eisenhower is a surname derived from the German word Eisenhauer, meaning "iron hewer". Notable people with the surname include:
David Eisenhower (born 1948), historian, son of John Eisenhower
Doud Eisenhower (1917–1921), infant son of future-President Dwight D. Eisenhower and Mamie Eisenhower
Dwight D. Eisenhower (1890–1969), five-star general and 34th President of the United States
Earl D. Eisenhower (1898–1968), American electrical engineer and politician, brother of President Dwight D. Eisenhower
Edgar N. Eisenhower (1889–1971), American lawyer, brother of President Dwight D. Eisenhower
Jennie Elizabeth Eisenhower (born 1978), actress, daughter of David and Julie Eisenhower
John Eisenhower (1922–2013), U.S. Army officer, son of President Dwight D. Eisenhower and Mamie Eisenhower
Julie Nixon Eisenhower (born 1948), daughter of Richard Nixon and wife of David Eisenhower
Mamie Eisenhower (1896–1979), wife of President Dwight D. Eisenhower
Mary Jean Eisenhower (born 1955), international charity worker, daughter of John Eisenhower
Milton S. Eisenhower (1899–1985), American University President, brother of President Dwight D. Eisenhower
Susan Eisenhower (born 1951), author and expert on international security, daughter of John Eisenhower