Efraín is a masculine Spanish given name, a cognate of Ephraim. Notable people with the name include:
Efrain Chacurian (born 1924), Argentine-born naturalised American soccer player
Efraín Cortés (born 1984), Colombian football defender
Efraín Escudero (born 1986), Mexican mixed martial arts fighter
Efraín Flores (born 1958), Mexican football manager
Efraín Forero Triviño (born 1931), Colombian cyclist
Efraín Goldenberg (born 1929), Peruvian politician
Efrain Gonzalez (born 1948), Puerto-Rico born New York senator
Efrain Guigui (1925-2007), US-based Panaman clarinetist and conductor.
Efraín Guzmán (circa 1937-2002), Colombian guerrilla leader
Efraín Huerta (1914-1982), Mexican poet
Efraín Juárez (born 1988), Mexican football player
Efraín López Neris (born 1937), Puerto Rican actor
Efraín Medina (born 1979), Mexican singer
Efraín Morote (circa 1925-1991), Peruvian anthropologist
Efraín Ríos (living), Cuban tres player
Efraín Ríos Montt (born 1926), former de facto President of Guatemala
Efraín Rivera Pérez (born 1951), Associate Justice of the Supreme Court of Puerto Rico
Efraín Sánchez (born 1926), Colombian footballer
Efrain Toro (living), Puerto Rican percussionist
Efraín Valdez (born 1966), Dominican Republic baseball player
Efraín Velarde (born 1986), Mexican football player
