Edward Spencer may refer to:
Edward Spencer (athlete) (1881–1965), British race walker
John Spencer, 8th Earl Spencer (Edward John Spencer, 1924–1992), British peer, father of Diana, Princess of Wales
Edward Spencer (English politician) (1594–1656), English politician who sat in the House of Commons at various times between 1621 and 1648
Edward Spencer (Canadian politician) (1893–1973), civil engineer and politician in Newfoundland
Edward Spencer (rugby union) (1876–1931), Scottish rugby player
Tubby Spencer (Edward Russell Spencer, 1884–1945), American baseball player
