Echols is a surname. Notable people with the surname include:
Alice Echols, American cultural critic and historian
Antwun Echols (born 1971), American boxer
Cameron Echols (born 1981), American basketball player
Damien Echols (born 1974), one of the West Memphis Three
Dondre Echols (born 1993), American hurdler
Edward Echols (1849–1914), American politician
Fate Echols (1939-2002), American football player
Jennifer Echols, American writer
John Echols (disambiguation) or Johnny Echols, multiple people
Joseph Hubbard Echols (1816–1885), American politician
Leonard S. Echols (1871–1946), American politician
Mike Echols (1944–2003), American writer
Mike Echols (American football) (born 1978), American football player
M. Patton Echols (1925–2012), American politician
Odis Echols (1930–2013), American politician, radio broadcaster and lobbyist
Oliver P. Echols (1892–1954), American military officer
Robert L. Echols (born 1941), American judge
Robert Milner Echols (1798–1847), American politician
Sheila Echols (born 1964), American athlete
Tim Echols, American politician
Vanessa Echols (born 1960), American television journalist
William Holding Echols (1859–1934), American academic