Eccles is a surname. Notable people with the surname include:
Ambrose Eccles (died 1809), Irish Shakespearean scholar
Clancy Eccles (1940–2005), Jamaican musician
David Eccles (businessman) (1849–1912), American businessman who became Utah's first multimillionaire
David Eccles, 1st Viscount Eccles (1904–1999), British Conservative politician
George S. Eccles (1900–1982), businessman and philanthropist
Graham Eccles, rugby league footballer of the 1960s, '70s and '80s for Leeds, and Wakefield Trinity
Henry Eccles (composer) (1670–1742),
Henry E. Eccles (1898–1986), Rear Admiral in the United States Navy
James Eccles (1838–1915), English mountaineer and geologist
John Carew Eccles (1903–1997), Australian physiologist
John Eccles (1668–1735), British composer
Marriner Stoddard Eccles (1890–1977), U.S. banker, economist, and Chairman of the Federal Reserve
Mary Eccles, Viscountess Eccles (1912–2003), book collector and scholar
Solomon Eccles (1618–1683), English musician
Spencer Eccles (born 1934), a prominent financier and philanthropist in Salt Lake City, Utah
Tony Eccles (1970), English darts player
William Henry Eccles (1875–1966), British physicist
William J. Eccles (1917–1998), historian of Canada