Trisha Shetty

EVH1 domain

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Symbol  EVH1
Pfam clan  CL0266
SMART  WH1
Pfam  PF00568
InterPro  IPR000697
SCOP  1evh
EVH1 domain

The EVH1 domain (also known as the WH1, RanBP1-WASP, or enabled/VASP homology 1 domain) is an evolutionary conserved protein domain.

The EVH1 domain is found in multi-domain Ena/Vasp homology proteins implicated in a diverse range of signalling, nuclear transport and cytoskeletal events. This domain of around 115 amino acids is present in species ranging from yeast to mammals. Many EVH1-containing proteins associate with actin-based structures and play a role in cytoskeletal organisation. EVH1 domains recognise and bind the proline-rich motif FPPPP with low-affinity, further interactions then form between flanking residues.

WASP family proteins contain an EVH1 (WH1) in their N-terminus which bind proline-rich sequences in the WASP interacting protein. Proteins of the RanBP1 family contain a WH1 domain in their N-terminal region, which seems to bind a different sequence motif present in the C-terminal part of RanGTP protein.

Tertiary structure of the WH1 domain of the Mena protein revealed structure similarities with the pleckstrin (PH) domain. The overall fold consists of a compact parallel beta-sandwich, closed along one edge by a long alpha helix. A highly conserved cluster of three surface-exposed aromatic side-chains forms the recognition site for the molecule's target ligands.

Examples

Human genes encoding proteins containing the EVH1 domain include:

  • ENAH, EVL
  • HOMER1, HOMER2, HOMER3
  • SPRED1, SPRED2, SPRED3
  • VASP, WAS, WASL
  • References

    EVH1 domain Wikipedia


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