Supriya Ghosh (Editor)

ETFA

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Species
  
Human

Entrez
  
2108

Human
  
Mouse

Ensembl
  
ENSG00000140374

ETFA

Aliases
  
ETFA, EMA, GA2, MADD, electron transfer flavoprotein alpha subunit

External IDs
  
MGI: 106092 HomoloGene: 100 GeneCards: ETFA

Electron-transfer-flavoprotein, alpha polypeptide (glutaric aciduria II), also known as ETFA, is a protein which in humans is encoded by the ETFA gene.

ETFA participates in catalyzing the initial step of the mitochondrial fatty acid beta oxidation. It shuttles electrons between primary flavoprotein dehydrogenases and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. Defects in electron-transfer-flavoprotein have been implicated in type II glutaricaciduria in which multiple acyl CoA dehydrogenase deficiencies result in large excretion of glutaric, lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids.

References

ETFA Wikipedia


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