Symbol esxA PDB 3FAV | Entrez 886209 UniProt P0A564 | |
ESAT-6, the 6 kDa early secretory antigenic target produced by Mycobacterium tuberculosis, is a secretory protein and potent T cell antigen. It is used in tuberculosis diagnosis by the whole blood interferon γ test QuantiFERON-TB Gold, in conjunction with CFP-10 and TB7.7.
ESAT-6 has been shown to directly bind to the TLR2 receptor, inhibiting downstream signal transduction.
References
ESAT-6 Wikipedia(Text) CC BY-SA