Species Human Entrez 64167 | Human Mouse Ensembl ENSG00000164308 | |
Aliases ERAP2, L-RAP, LRAP, endoplasmic reticulum aminopeptidase 2 External IDs HomoloGene: 75183 GeneCards: ERAP2 | ||
Endoplasmic reticulum aminopeptidase 2 is a protein that in humans is encoded by the ERAP2 gene.
Function
Aminopeptidases hydrolyze N-terminal amino acids of proteins or peptide substrates. Major histocompatibility complex (MHC) class I molecules rely on aminopeptidases such as ERAP1 and LRAP to trim precursors to antigenic peptides in the endoplasmic reticulum (ER) following cleavage in the cytoplasm by tripeptidyl peptidase II (TPP2).
References
ERAP2 Wikipedia(Text) CC BY-SA