Girish Mahajan

EPHB6

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Species  Human
Entrez  2051
Human  Mouse
Ensembl  n/a
EPHB6
Aliases  EPHB6, HEP, EPH receptor B6
External IDs  MGI: 1096338 HomoloGene: 20940 GeneCards: EPHB6

Ephrin type-B receptor 6 is a protein that in humans is encoded by the EPHB6 gene.

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The ephrin receptor encoded by this gene lacks the kinase activity of most receptor tyrosine kinases and binds to ephrin-B ligands.

References

EPHB6 Wikipedia


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