Species Human Entrez 317649 | Human Mouse Ensembl ENSG00000163412 | |
Aliases EIF4E3, eIF-4E3, eIF4E-3, eukaryotic translation initiation factor 4E family member 3 External IDs MGI: 1914142 HomoloGene: 41652 GeneCards: EIF4E3 | ||
Eukaryotic translation initiation factor 4E family member 3 is a protein that in humans is encoded by the EIF4E3 gene.
EIF4E3 belongs to the EIF4E family of translational initiation factors that interact with the 5-prime cap structure of mRNA and recruit mRNA to the ribosome.
Model organisms
Model organisms have been used in the study of EIF4E3 function. A conditional knockout mouse line, called Eif4e3tm1a(KOMP)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty four tests were carried out on mutant mice but no significant abnormalities were observed.