Species Human Entrez 1959 | Human Mouse Ensembl ENSG00000122877 | |
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Aliases EGR2, AT591, CMT1D, CMT4E, KROX20, early growth response 2 External IDs MGI: 95296 HomoloGene: 20123 GeneCards: EGR2 | ||
Early growth response protein 2 is a protein that in humans is encoded by the EGR2 gene.
Function
The early growth response protein 2 is a transcription factor with three tandem C2H2-type zinc fingers. Mutations in this gene are associated with the autosomal dominant Charcot-Marie-Tooth disease, type 1D, Dejerine–Sottas disease, and Congenital Hypomyelinating Neuropathy. Two studies have linked EGR2 expression to proliferation of osteoprogenitors and cell lines derived from Ewing sarcoma, which is a highly aggressive bone-associated cancer.
References
EGR2 Wikipedia(Text) CC BY-SA