Species Human Entrez 1890 | Human Mouse Ensembl ENSG00000025708 | |
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Aliases TYMP, thymidine phosphorylase, ECGF, ECGF1, MEDPS1, MNGIE, MTDPS1, PDECGF, TP, hPD-ECGF External IDs MGI: 1920212 HomoloGene: 1474 GeneCards: TYMP | ||
Thymidine phosphorylase is an enzyme that in humans is encoded by the TYMP gene.
Platelet-derived endothelial cell growth factor (ECGF1) is an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. ECGF1 has a highly restricted target cell specificity acting only on endothelial cells. Because it limits glial cell proliferation, ECGF1 is also known as thymidine phosphorylase and as gliostatin. The ECGF1 gene contains 10 exons spanning more than 4.3 kb. Thymidine phosphorylase activity of ECGF1 in leukocytes from mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) patients was less than 5 percent of controls, indicating that loss-of-function mutations in thymidine phosphorylase cause MNGIE.
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles.