Neha Patil

ECGF1

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Species  Human
Entrez  1890
Human  Mouse
Ensembl  ENSG00000025708
ECGF1
Aliases  TYMP, thymidine phosphorylase, ECGF, ECGF1, MEDPS1, MNGIE, MTDPS1, PDECGF, TP, hPD-ECGF
External IDs  MGI: 1920212 HomoloGene: 1474 GeneCards: TYMP

Thymidine phosphorylase is an enzyme that in humans is encoded by the TYMP gene.

Platelet-derived endothelial cell growth factor (ECGF1) is an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. ECGF1 has a highly restricted target cell specificity acting only on endothelial cells. Because it limits glial cell proliferation, ECGF1 is also known as thymidine phosphorylase and as gliostatin. The ECGF1 gene contains 10 exons spanning more than 4.3 kb. Thymidine phosphorylase activity of ECGF1 in leukocytes from mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) patients was less than 5 percent of controls, indicating that loss-of-function mutations in thymidine phosphorylase cause MNGIE.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.

References

ECGF1 Wikipedia


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