Dworkin is a surname. Notable people with the surname include:
Aaron Dworkin (born 1970), musician and activist
Andrea Dworkin (1946–2005), feminist writer
David Dworkin (born 1934), musician
Dorothy Dworkin (1889–1976), nurse, businesswoman and philanthropist
Gerald Dworkin (born 1937), legal philosopher
Keith Dworkin, playwright
Ronald Dworkin (1931–2013), legal philosopher
Ronald W. Dworkin, anesthesiologist