Durham is a surname. Notable people with the surname include:
Bartlett S. Durham (1824–1859), American physician and the namesake of Durham, North Carolina
David Anthony Durham (born 1969), American novelist
Edward B. Durham (c. 1870 - c. 1930),American mining engineer and Professor
Geoffrey Durham (born 1949), British comedy magician and actor
Hugh Durham (born 1937), American college basketball coach
Jim Durham (born 1947), American sportscaster
Judith Durham (born 1943), Australian singer, member of The Seekers
Leon Durham (born 1957), American baseball player
Philip Charles Durham (1763–1845), British admiral who fought at the Battle of Trafalgar
Ray Durham (born 1971), American baseball player
Rhea Durham (born 1978), American fashion model
Ron Durham (born 1921), Australian rules footballer
Woody Durham (born 1941), American radio announcer
