Dumitrescu is a Romanian surname. Notable people with the surname include:
Alexandru Dumitrescu, sprint canoer
Constantin Dumitrescu (born 1931), boxer
Constantin Ticu Dumitrescu (1928–2008), politician
Cristian Dumitrescu (born 1955), politician
Daniel Dumitrescu (born 1968), boxer
Geo Dumitrescu, poet and journalist
George Dumitrescu, poet
George Dorul Dumitrescu, prose writer
Iancu Dumitrescu (born 1944), avant-garde composer
Ilie Dumitrescu (born 1969), soccer player
Ion Dumitrescu (1925–1999), sports shooter and Olympic champion
Liana Dumitrescu (1973–2011), politician
Nelu Dumitrescu, drummer
Natalia Dumitrescu, abstract painter
Petre Dumitrescu (1882–1950), general
Răzvan Dumitrescu, journalist
Ruxandra Dumitrescu, volleyball player
Sava Dumitrescu, pharmacologist and professor
Vasile Dumitrescu, bobsledder
Victor Dumitrescu (1924–1997), soccer player
Zamfir Dumitrescu (born 1946), painter
Zoe Dumitrescu-Bușulenga, literary critic and philosopher