Dufresne or du Fresne ([dyfʁɛːn]) is a French topographical name from Old French meaning "ash" as in Ash tree from the Latin: fraxinus. Notable people with the surname include:
Begona Via Dufresne (born 1971), Spanish sailor and Olympic champion
Charles Dufresne (1876-1938), French painter
Diane Dufresne (born 1944), Canadian singer and painter
Donald Dufresne (born 1967), retired Canadian ice hockey defenceman
Gaston Dufresne (1898–1998), contrabassist in the Boston Symphony Orchestra
Gérard Dufresne (1918–2013), local politician and a military officer in Shawinigan, Quebec
Guillaume Dufresne d'Arsel, established French rule of Mauritius under the French East India Company in 1715
Jean Dufresne (1829–1893), German chess player
John Dufresne (born 1948), American author of French Canadian descent
Joseph Dufresne (1805–1873), Quebec notary and political figure
Laurent Dufresne (born 1972), former Team Captain of Valenciennes FC
Louis Dufresne (1752–1832) French explorer, ornithologist and taxidermist
Marc-Joseph Marion du Fresne (1724–1772), French explorer
Nicole duFresne (born 1973), Spanish sportive sailor
Sylvain Dufresne (born 1978), Canadian ice hockey defenceman
Wylie Dufresne (born 1970), chef and owner of wd~50 restaurant in Manhattan
Andy Dufresne, the protagonist of the 1994 American drama film, The Shawshank Redemption
Frank 'Doc' DuFresne, a character in the web series, Red vs. Blue
